Further studies on the inhibition of rat hepatic dimethylnitrosamine metabolism in vitro.
نویسندگان
چکیده
Amador, E., Zirnrnerman, T. S. & Wacker, W. E. C. (1963)J. Am. Med. Ass. 185,769-775 Ellis, B. G., Price, R. G. & Topham, J. C. (1973) Chern. Biol. Interact. 7, 101-113 Gryd-Hansen, N. (1974) Histochern J. 6,199-209 Leathwood, P. D., Gilford, M. K. & Plummer, D. T. (1972) Enzymologia 42,285-301 Price, R. G., Dance, N. &. Robinson, D. (1971) Eur. J. Clin. Invest. 2,47-51 Raab, W. P. (1966) Klin. Wochenschr. 78,364-369 Raab, W. P. (1972) Clin. Chern. 18,5-25 Wright, P. J. & Plummer, D. T. (1974) Biochern. Pharmacof. 23,65-73
منابع مشابه
Comparative studies on hepatic dimethylnitrosamine demethylase and some xenobiotic-metabolizing enzymes in the rat.
Dimethylnitrosamine is a potent hepatocarcinogen in a number of animal species including the rat (Magee & Barnes, 1956). Previous investigations into the hepatic metabolism of dimethylnitrosamine in vitro have shown that this compound is metabolized to formaldehyde, a process requiring NADPH and molecular oxygen (Magee & Vandekar, 1958). The requirement for these two cofactors has led to the su...
متن کاملFurther studies on the metabolism of dimethylnitrosamine by rat liver in vitro [proceedings].
(Fig. 1 ) . These compounds also had some effect on the proportion of the 14C recovered in the urine. N-Nitrosopyrrolidine inhibits the metabolism of dimethylnitrosamine to formaldehyde by rat liver l O O O O g supernatant. The form of the dependence of the rate of dimethylnitrosamine metabolism to formaldehyde on inhibitor concentration (shown in Fig. 2) suggests that there is a competitive ef...
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1. Administration of a single dose of dimethylnitrosamine to rats temporarily fed on a protein-deficient diet causes a high incidence of kidney tumours. The effect of such a dose of dimethylnitrosamine (40mg/kg body wt.) on metabolism of nucleic acids and protein in rat liver and kidneys was examined during the week immediately after administration. 2. Incorporation of [(14)C]leucine and [(14)C...
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Incubation of rat hepatocytes with epinephrine inhibited alanine aminotransferase (ALT) (80%) and aspartate aminotransferase (AST) (53%) activities with no effect on lactate dehydrogenase (LDH) activity. Injection of epinephrine caused a progressive increase with time in hepatic LDH activity, being 52% at 24 h. Preinjection with propranolol eliminated the hormone effect and caused further ...
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Background Nicotine, cotinine and cadmium are harmful components of cigarettes that have an effect on human reproductive function. Although the effects of cigarette smoke on male reproductive function is characterized in several articles its mechanism of action is still unknown. In the present study, we investigate the effect of nicotine, cotinine and cadmium on human sperm creatine kinase acti...
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ورودعنوان ژورنال:
- Biochemical Society transactions
دوره 4 4 شماره
صفحات -
تاریخ انتشار 1976